Description
COMPOSITION :
Each capsule Lando-150 contains
Clindamycin base 150 mg as
Clindamycin.HCL.H2O
Each capsule Lando-300 contains
Clindamycin base 300 mg as
Clindamycin HCL.H2O
ACTION
Clindamycin is an antimicrobial and acts by inhibition of protein synthesis binding 50 S ribrosomal sub-units of susceptible
organism.
Clindamycin is effective against Streptococcus pyogenes, Streptococcus pneumonia, Streptococcus viridans and Staphylococcus
aureus (either sensitive or resistant to penicilins and including the penicillinase-producing).
Lando is absorbed almost completely after oral administration. Peak concentration in blood is reached within 1 hour.
The drug penetrates quickly into the tissue, body, fluids, skeleton and pus. Its half life is 2.5 hours and primarily eliminated
through the liver.
INDICATION
Serious infections caused by organisms sensitive of Clindamycin include upper and lower respiratory tract infections, otitis
media, skin infections, osteomyclitis, anaerobic infections.
CONTRA INDICATION
Patients hypersensitive to Clindamycin.
Patients with diarrhea, liver and kidney function disturbances.
Atopic individuals, e.g. the asthmatic and allergic patients. It is not indicated for the treatment of mild infections caused by
bacteria and viruses.
SIDE EFFECTS
Hypersensitive reactions e.g. urticaria, skin rash and pruritus. Gastrointestinal disturbances, e.g. nausea, vomiting, diarrhea
and colitis.
DOSAGE
Adult :
For serious infections : 150-300 mg, 6-hourly.
For more severe infections : 450 mg, 6-hourly.
Children more than 1 month old :
For serious infections : 8-16 mg/kg body weight/day given in 3-4 divided doses.
For more severe infections : 16-20 mg/kg body weight / day given in 3-4 divided doses.
WARNING AND PRECAUTIONS
Use in pregnancy and lactating mothers and new born infants has not been elucidated.
Caution should be exercised in administering the antibiotics to patients with allergy and asthmatic.
Clindamycin therapy has been associated with severe colitis which may end fatally.
When Clindamycin is indicated in the patients, they should be carefully monitored for change in bowel frequency.
Lando capsule should be prescribed with caution in individuals with a history of gastrointestinal disease. During prolonged
therapy, periodic liver and kidney function test and blood counts should be performed.
The use of Lando occasionally results in overgrowth of non-susceptible organism-particularly yeast.
STORAGE
In a cool and dry place.
PRESENTATION
Lando-150 : Box of 10×10’s. Reg.No. DKL9421007401B1
Lando-300 : Box of 5×10’s. Reg.No. DKL9421007401C1
On medical prescription only.
