Description

COMPOSITION :
Each capsule contains 250 mg Ciprofloxacin ( as HCl )
Each caplet contains 500 mg Ciprofloxacin ( as HCl )

ACTIONS :
Ciprofloxacin inhibits bacterial DNA synthesis. It does not affect the biosynthesis of bacterial cell wall at the proliferation stage.
However it selectively destroys the genetic substance as bacteria needs DNA at proliferation stage and at non active stage.
Ciprofloxacin is effective at non – active or during replication period of bacterial cell.

INDICATIONS :
Treatment of infections caused by bacterial pathogen, eg urinary tract infections ( except prostatitis ), urethritis and gonorrheal
cervicitis, gastrointestinal tract infections, eg typhoid and paratyphoid, respiratory ( except pneumonia caused by streptococcus
), skin and soft tissue, bones and joints infections.

DOSAGE & ADMINISTRATION :
Mild to Moderate Urinary Tract Infections; 2 x 250 mg caps a day.
Severe Urinary Tract Infections : 2 x 500 mg caplets a day.
Mild to Moderate Respiratory Infections, Bones and Joints Infections, Skin and Soft Tissue Infections: 2 x 500 mg
caplets a day.
For severe Infections : 2 x 750 mg a day.
Gastrointestinal Infections: 2 x    500 caps a day.
Acute Gonorrhea: Single Dose : 250 mg.
Acute Osteomyelitis : Dosage should not be less than 2 x 750 mg a day to achieve adequate level.
In patients with renal impairment ( creatinine clearance < 20 ml/min), recommended dose is once daily of a normal
unit dose or reduced to ½ if given twice a daily.

CONTRAINDICATIONS :
Patients known to be hypersensitive to ciprofloxacin or other quinolone derivatives. Pregnant and lactating women. Children
and adolescents.

PRECAUTIONS :
Patients who suffered from previous  cerebral disorders can only take Volinol if patients are receiving appropriate
anticonvulsant treatment. To avoid crystaluria, it is recommended to swallow Volinol with plenty of water. Care should be taken
when giving the medication to patients with renal impairment ( see Dosage & Administration ). The recommended dose should
not be exceeded.

SIDE EFFECTS :
In general, side effects are rarely reported . However, the following side effects have been reported : Gastrointestinal
disturbances, eg nausea, vomiting, diarrhea, dyspepsia, abdominal pain.
Central nervous system disturbances, eg headache, dizziness, tiredness and sometimes blurred vision. Skin reactions .
Transient increase of liver enzyme, particularly in patients who suffered from previous liver impairment.

INTERACTIONS :
Antacids which contain aluminium and magnesiun affect the absorption of Volinol. Therefore, Volinol should be taken 1 – 2 hrs
before or after taking the antacids. Concurrent administration of 1500 mg or more of Volinol a day and theophylline can cause
undesirable increase in the serum theophylline concentration. If concurrent use of these 2 products is unavoidable, serum
concentration of thephylline must be monitored, if necessary theophylline dose should be reduced. Interactions may occur if
Volinol is administered together with probenecid, metronidazole and clindamycin.

PACKING :
Volinol-250 capsule. Box of 5×6’s. Reg.No. DKL9321006901A1.
Volinol-500 caplet.   Box of 5×6’s. Reg.No. DKL9321006804A1.

On medical prescription only.